Tuesday, May 21, 2019
6 steps decision making Essay
In addition to time blackmails that we en t anyyer when searching for incompatibleiate to support care stopping points for individual unhurrieds, it may be difficult for clinicians to apply the license that we find. The dictate limiting step may non be doing the search, but the steps leaded in setting depict-based practice of medical specialty (EBM) in motion. We present an example of a search for evidence by a Physician Assistant (PA) bookman that highlights this challenge. PAs receive accelerated training in the medical model and work in teamsunder physician supervision. Approximately 40 000 PAs authenticly work in theUS in a all-encompassing range of settings and specialties.Practising EBM has become an important component of training for PAs.During an internecine medicine rotation, a PA pupil encountered a common clinical practice uncorroborated by currentevidenceadministration of nebulised albuterol in patients with community acquired pneumonia ( roof). While th is practice maybe justified in patients with underlying continuing obstructive pulmonary disease (COPD) who also present with CAP, this schoolchild interrogative sentenceed the grounds for its routine in patients with CAP who do not have COPD.Clinical scenarioA 68 year old man presented to the emergency department with fever, chills, and a non-productive cough of 1 weeks duration. He had fatigue, headache, rhinorrhoea, and mild nausea, butdenied dyspnoea. He had no history of smoking or COPD. Hehad atrial fibrillation and was taking warfarin for stroke prevention. On admission, his temperature was 38.4 C, heart rate was108 beats/minute, respiratory rate was 24 breaths/minute,blood pressure was 156/88 mm Hg, and oxygen saturation was86% by pulse oximetry on room air. Rales were heard in twainlung bases and in the right middle lobe. Chest radiographyshowed a diffuse infiltrate in the right middle and lower lobes. Complete blood count showed a white blood cell count of22 000 cells/ ml with a left(p) shift, and arterial blood gases showed mild respiratory acidosis.One battery-acid of ceftriaxone was administered parenterally, and a course of azithromycin was started. Albuterol, 5% solution,delivered by nebuliser 3 times daily was also ordered, in addition to a combination of inhaled ipratropium and albuterol,delivered by metered dot inhaler every 4 hours as needed.During the hospital stay, his pneumonia resolved, but his heart rate increased to 150 beats/minute and his blood pressure uprise from 156/88 to 200/110 mm Hg.Clinical questionAlthough there was no institutional protocol for use ofnebulised albuterol for discourse of CAP, the house ply often ordered it.The PA student queried In a 68 year old man with CAP and no underlying COPD, does use of nebulised 2 agonists improve symptoms? What is the risk of harm in thispatient?Search strategyFirstly, a treatment guideline was sought to clarify recommendations regarding use of nebulised albuterol for treatm ent of CAP.The American Thoracic Society guidelines for management ofCAP1 were rapidly retrieved through PubMed, UpToDate, andMD Consult. The British Thoracic Society (BTS) guidelines for the management of CAP in adults2 were also demonstrate in PubMed.Both sets of guidelines were relevant to our patient, but neither guideline discussed the use of nebulised albuterol in thetreatment of CAP. The BTS guidelines had a section on ecumenic management, which discussed the use of adjunctive therapiesfor CAP, but nebulised albuterol was not mentioned. Evidence from controlled clinical trials was mentioned in the guideline for bottle blowing,3 but not for physiotherapy.Having not fully answered our question with a review ofrelevant guidelines (and having not attracted the attention of anyone who could change the patients treatment plan), wesearched PubMed again, this time specifically for studies on the use of albuterol in patients with CAP.No relevant trials were found on the use of nebu lisers for CAP.To identify evidence about harm with the use of albuterol,PubMed was searched using the terms nebulised albuterol, cardiac arrhythmias, and randomised or controlled clinical trials.No trials were found. When just the content terms weresearched, 9 articles, not directly relevant to our patient, were found. One prospective, open label study on the work ofnebulised albuterol (for treatment of asthma) on cardiac rhythm was found.4 10 patients were studied, and although no adverse effect on cardiac rhythm or blood pressure was found, the study did not convince the team that no potential for harm existed in this, or other patients, especially when therewas no clear trace for use of albuterol.Recognising that searching and appraising the literature are not the only important aspects of practicing EBM, we consulted an experienced pulmonologist, who practises and teaches using the EBM model. In addition to reviewing treatment plans formultiple cases of CAP requiring hospital admission with theNurse Practitioner/Physician Assistant service, he recommended review of the Centre for Evidence-Based Medicinewebsite at Mount Sinai Hospital in Toronto, Ontario, Canada(www.cebm.utoronto.ca/), which suggested blether blowing as a method for helping clear secretions.23 This served as anexcellent, rapid approach to finding good information on treatment of CAP, and substantiate the evidence previously found inthe literature search.Application of the evidence to this, and futurepatientsThe treatment plan for this patient was not altered by thestudents rapid search for evidence. Changes in usual care for a common illness required a comprehensive search and discussion among all clinicians in our institution caring for patientswith CAP.The clinical team reviewed the results of the search and because no evidence was found to support use of albuterol in patients like ours, changes were puzzle to future practice. As a result of this put to work, which took a few hours and evolved over several weeks, orders for bronchodilators for patients with CAP are now made on an individual basis, depending on thepresence of patient comorbid illnesses, much(prenominal) as COPD.164 Volume 8 November/December 2003 EBM www.evidence-basedmedicine.com EBM notebook Downloaded from ebm.bmj.com on 10 August 2009ConclusionThe need for a rapid search for evidence is sometimes, but not al styluss, important to the care of an individual patient. In this case, the speed of the search did not happen upon the ability of the PA student to apply theevidence to the patient. Setting the evidence in motion may require communication of search results to other members of the clinical team and may affect the care of future patients. Although the catalyst for setting EBM in motion was a student, the evidence, including the results of further research, along with the judgment of the experienced pulmonologist,convinced the clinical team to make changes to usual care and to base futu re treatment of this common condition on the best available evidence.The basic concept of evidence-based medicine proposes tomake wellness related decisions based on a synthesis of internal and orthogonal evidence. Internal evidence is composed of cognition acquired through formal education and training, generalexperience accumulated from daily practice, and specificexperience gained from an individual clinician-patient relationship. External evidence is accessible information from research.It is the explicit use of valid external evidence (eg, randomised controlled trials) combined with the prevailing internal evidence that defines a clinical decision as evidence-based. To realise this concept in day to day clinical practice, the Evidence- Based Medicine Working Group proposed a 5 step strategy,corresponding to step 1 and steps 3 to 6 shown in the left hand column of the table.In teaching this 5 step approach, we encountered several difficulties. We noticed a growing hesitance to accept this strategyas students locomote in their medical training. In the presence of well established methods of treatment or diagnosis, thisresistance rises even more, regardless of the level of training.We assume that this barrier is associated with the process of socialisation into the health professions. Throughout medicaleducation students are virtually trained to make decisions under the condition of uncertainty. Advanced students and to a greater boundary clinicians lose some of their ability to differentiate between scientific evidence and what seems to be evident. If we intend to implement evidence-based medicine more efficiently, we need to modify the way students and clinicians learn to make decisions.Therefore, an additional step was introduced in our evidencebased medicine teaching programme (step 2 in the table).Students were to provide answers to their clinical questions based on their current knowledge (internal evidence) beforecontinuing with the remaining steps of the evidence-basedprocess.2 Our collective experience concerning this additional step was extremely positive. The students using this new step were satisfied that their preexisting knowledge had beenintegrated into the evidence-based approach. By explicitlydocumenting their internal evidence, students used the remaining steps of the process to evaluate not only the best evidence in do a clinical decision but also to assess the accuracy of their internal evidence, the grounds upon which their preconcep-The 6 steps of evidence-based decision making gradation Action Explanation1 Transformation of the clinical problem into 3 or 4 part question (a) relevant patient characteristics and problem(s), (b) leading intervention, (c) option intervention, (d) clinical outcomes or goals. 2 Additional step answer to the question based on internal evidence only Internal evidence acquired knowledge through professional training and experience (in general and applied to the patient). Should be d ocumented before proceeding to step 3.3 Finding external evidence to answer the question External evidence obtained from textbooks, journals, databases, experts. The value of the external evidence will be highly variable, see step 4. 4 Critical appraisal of the external evidence Should answer 3 questions (1) Are the results valid? (2) Are the results clinically important? (3) Do the results apply to my patient? (or is my patient so different from those in the study that the results do not apply?) 5 Integrating external and internal evidence The 2 sources of information (external and internal) may be supportive, non-supportive, or conflicting. How the decision is made when non-supportive or conflicting will depend on multiple factors. 6 Evaluation of decision making process Once the decision has been made, the process and the outcome are considered and opportunities for improvement are identified.The health authority of Alto Adige in northern Italy initiated and supported a project, the Bressanone Model, in which the effects of implementing evidence-based medicine on the prime(a) of health care were to be shown. In this model we used the six step approach, which proved to be successful in the studentproject to teach experienced clinicians.3 The participants were asked to name problems of their day to day practice that lacked either an effective or an efficient solution. The evidence-based medicine support group helped participants to articulate the 3 or 4 part questions. Subsequently, the physicians were asked to submit their individual answers to the questions before continuing with steps 3 to 6.Agreement between internal and external evidence varies.Completing the full process could result in finding evidence that confirms the internal evidence, validating and strengthening the clinicians or students combine in the decision. The process could also reveal that little evidence exists to support the decision or that the available evidence is equivocal. In suc h cases, other factors such as cost or inconvenience to the patient may need to be given greater consideration. Possibly, the best external evidence found is not in agreement with the internal evidence. This represents a particularly valuable experience for the clinician or student because it may avoid an ill advised decision. It also shows the fallibility of making decisions onuncertain ground based on internal evidence alone. This in turn will hopefully promote the routine assimilation of external evidence in clinical decision making. The documentation andcomparison of steps 2 and 5, used as a research tool or quality assurance outcome measure, could provide valid informationon the effects of evidence-based medicine on clinical decision making.In case of conflicting internal and external evidence, clinicians have several options. They may change their mind and align it with the external evidence. They may determine that the external evidence is not sufficiently convert and remain with theoriginal decision. Or, they may choose to discuss with thepatient the conflict between the internal and external evidence in a manner that enables the patient to take part in the decision making process. This last approach is recommended becausepatient preference is considered an essential part of theevidence-based decision making process1 and decisions oftenneed to be made in the absence of clear research findings.